RNA editing, specifically, adenosine to inosine deamination catalyzed by adenosine acting on RNA enzymes (ADAR editing) plays a key role in increasing neural transcriptome diversity by expanding the number of distinct functional proteins. Changes in ADAR editing of specific genes have been documented in neurodegeneration, including Alzheimer and Parkinson’s diseases, as well as major mental health disorders. By using comparative genomics approaches, we identified orthologous and homologous editing target genes shared between two genomes. We are currently comparing their editing status across different neural populations in two species, as well as between healthy and disordered individuals. The contributions of multiple ADAR loci in human versus that of a single ADAR locus in Drosophila will also be examined. The obtained results will provide insights into the nuanced spatio-temporal regulation of editing patterns in the brain by contrasting editing patterns between human candidate target genes and those edited in Drosophila brain.