1. Open Access Kent State
  2. Methods for characterizing interspike intervals and identifying bursts in neuronal activity
Author(s)
Abstract

Neurons produce complex patterns of electrical spikes, which are often clustered in bursts. The patterns of spikes and bursts can change substantially when neurons are exposed to toxins and chemical agents. For that reason, characterization of these patterns is important for the development of neuron-based biosensors for environmental threat exposure. Here, we develop a quantitative approach to describe the distribution of interspike intervals, based on plotting histograms of the logarithm of the interspike interval. This approach provides a method for automatically classifying spikes into bursts, which does not depend on assumptions about the burst parameters. Furthermore, the approach provides a sensitive technique for detecting changes in spike and burst patterns induced by pharmacological exposure. Hence, it is suitable for use both as a research tool and for deployment in a neuron-based biosensor.
Format
Article
Identifier(s)
10.1016/j.jneumeth.2006.12.003
Publication Date
2007-05
Publication Title
Journal of Neuroscience Methods
Publisher
Elsevier BV
Volume
162
Issue
1
First Page
64
Last Page
71
Keywords
Rights
http://rightsstatements.org/vocab/InC/1.0/
License
https://www.elsevier.com/tdm/userlicense/1.0/
Community
Advanced Materials and Liquid Crystal Institute
Department of Physics
PDF URL
https://www.sciencedirect.com/science/article/pii/S0165027006006029
Permalink https://oaks.kent.edu/article/methods-characterizing-interspike-intervals-and-identifying-bursts-neuronal-activity
Selinger, J., Kulagina, N., O’Shaughnessy, T., Ma, W., & Pancrazio, J. (2007). Methods for characterizing interspike intervals and identifying bursts in neuronal activity. Journal of Neuroscience Methods. https://doi.org/10.1016/j.jneumeth.2006.12.003
Selinger, Jonathan, Nadezhda Kulagina, Thomas O’Shaughnessy, Wu Ma, and Joseph Pancrazio. 2007. “Methods for Characterizing Interspike Intervals and Identifying Bursts in Neuronal Activity”. Journal of Neuroscience Methods. https://doi.org/10.1016/j.jneumeth.2006.12.003.
Selinger, J., N. Kulagina, T. O’Shaughnessy, W. Ma, and J. Pancrazio. Methods for Characterizing Interspike Intervals and Identifying Bursts in Neuronal Activity. Journal of Neuroscience Methods, May 2007, doi:10.1016/j.jneumeth.2006.12.003.