Simple, rapid, and accurate spectrophotometrc procedures for the determination of the antibiotic rifampicin, in capsules, are presented. A chelate formation of the antibiotic with cupric ion and charge-transfer complexation with halogenated quinones are carried out. Linear correlations between absorbance and concentration over the range of 40-100 μg ml−1 were computed. The reaction pathways were proposed. The utility of copper chelate as a stability indicating procedure as well as a method to determine rifampicin In spiked urine samples is demonstrated.
Galal, Shereen M; Blaih, Salah; Abdel-Hamid, Mohamed E (1992). Comparative Spectrophotometrc Analysis of Rifampicin by Chelate Formation and Charge-Transfer Complexation. Analytical Letters 25(4) 725-743. doi: 10.1080/00032719208020030. Retrieved from https://oaks.kent.edu/chempubs/37