1. Open Access Kent State
  2. Determination of Some 1,4-Benzodiazepines by Oxidative Coupling of their Acid-Induced Degradation Products
Author(s)
Abstract

The oxidative coupling reaction of 3-methylbenzothiazolone hydrazone with aromatic amines was applied to the determination of five 1,4-benzodiazepine derivatives. The drugs were first hydrolyzed in acid medium and the liberated benzophenone derivatives were reacted with the chromogenic reagent in the presence of cerric ammonium sulphate to give a pink color. A linear correlation was found between the absorbance at λmax and concentration. The method was applied to the determination of these drugs in bulk powder and in pharmaceutical preparations. The procedure was extended to develop a stability-indicating method for these drugs.
Format
Article
Identifier(s)
10.1002/bscb.19931020403
Publication Date
1993-01-01
Publication Title
Bulletin des Sociétés Chimiques Belges
Volume
102
Issue
4
First Page
233
Last Page
237
Subject
Community
Department of Chemistry & Biochemistry
Permalink https://oaks.kent.edu/chempubs/38
El-Yazbi, F., Galal, S., & Blaih, S. (1993). Determination of Some 1,4-Benzodiazepines by Oxidative Coupling of their Acid-Induced Degradation Products. Bulletin des Sociétés Chimiques Belges. https://doi.org/10.1002/bscb.19931020403
El-Yazbi, Fawzy, Shereen Galal, and Salah Blaih. 1993. “Determination of Some 1,4-Benzodiazepines by Oxidative Coupling of Their Acid-Induced Degradation Products”. Bulletin des Sociétés Chimiques Belges. https://doi.org/10.1002/bscb.19931020403.
El-Yazbi, F., S. Galal, and S. Blaih. Determination of Some 1,4-Benzodiazepines by Oxidative Coupling of Their Acid-Induced Degradation Products. Bulletin des Sociétés Chimiques Belges, 1 Jan. 1993, doi:10.1002/bscb.19931020403.