Two simple and accurate methods are described for the determination of clindamycin hydrochloride. The spectrophotometric method involves the oxidation of the sulfur atom in this drug with potassium iodate in acidic medium with the liberation of iodine and subsequent extraction with cyclohexane followed by measuring the absorbance at 520 nm. The titrimetric method involves direct titration of the drug with N-bromosuccinimide. The relative standard deviation for both methods was less than 1%. The proposed methods were applied to the determination of the drug in pure and capsule forms.
El-Yazbi, Fawzy A; Blaih, Salah (1993). Spectrophotometric and Titrimetric Determination of Clindamycin Hydrochloride in Pharmaceutical Preparations. The Analyst 118(5) 577-579. doi: 10.1039/AN9931800577. Retrieved from https://oaks.kent.edu/chempubs/39