The natural world is responding to anthropogenic change through novel pathogens, antibiotic-resistant microbes, and pest infestations. This resurgence is part of a non-human reappropriation and transformation of human-altered environments. In this commentary, we argue that this ‘revanchism’ has prompted two new forms of genocide: the pre-emptive mass slaughter of non-human animals, and the annihilation of humans as expressed through COVID-19 and other pandemics; forms that will become exemplars for mass murder in the twenty-first century.