Purpose: This study aimed at examining differences in satisfaction with the employment situation between employed and unemployed Latinx with multiple sclerosis (MS) in the United States (N = 148). Method: Participants in this study responded to a national survey of the employment and community living concerns of people with MS. Multivariate analysis of variance and a follow-up univariate analysis of variance were conducted to compare the group differences. Results: The analyses revealed statistically significant between-group differences in satisfaction ratings on items pertaining to personal and environmental resources and fair treatment, but no significant between-group differences in response to items related to legal rights. Conclusion: The findings in this study confirmed our a priori expectation that satisfaction ratings regarding the overall employment situation among Latinx Americans with MS would vary as a function of their workforce participation status. Implications for future research and clinical practice in vocational rehabilitation in the COVID-19 era are discussed.