Two experiments using a state-dependent retention (SDR) design determined whether MK-801 blocked the acquisition and retention of an avoidance response. In Experiments 1 and 2, rats were trained and tested 30 min after injections of either saline or MK-801 (0.05 and 0.10 mg/kg, respectively). Two minutes after training, subjects were immediately tested, and in both experiments, the avoidance response was acquired. The 24-h retention tests for Experiment 1 revealed that the data marginally supported a SDR interpretation. In Experiment 2, the dose of MK-801 was increased to 0.10 mg/kg, and the results showed that MK-801 rendered passive avoidance (PA) state-dependent. These experiments indicate that neither the 0.05 nor 0.10 mg/kg doses of MK-801 prevented acquisition of the avoidance response and that the latter dose rendered memory for PA training state-dependent. It is suggested that doses of MK-801 that did not impair PA learning can function as a cue state and influence expression of memory for PA.
Pharmacology Biochemistry and Behavior
Harrod, Steven B.; Flint, Robert W.; Riccio, David C. (2001). MK-801 Induced Retrieval, but Not Acquisition, Deficits for Passive Avoidance Conditioning. Pharmacology Biochemistry and Behavior 69(3) 585-593. doi: 10.1016/S0091-3057(01)00565-2. Retrieved from https://oaks.kent.edu/psycpubs/34