1. Open Access Kent State
  2. GABA-mediated Presynaptic Inhibition is Required for Precision of Long-term Memory
Author(s)
Abstract

Though much attention has been given to the neural structures that underlie the long-term consolidation of contextual memories, little is known about the mechanisms responsible for the maintenance of memory precision. Here, we demonstrate a rapid time-dependent decline in memory precision in GABAB(1a) receptor knockout mice. First, we show that GABAB(1a) receptors are required for the maintenance, but not encoding, of a precise fear memory. We then demonstrate that GABAB(1a) receptors are required for the maintenance, but not encoding, of spatial memories. Our findings suggest that GABA-mediated presynaptic inhibition regulates the maintenance of memory precision as a function of memory age.
Format
Article
Identifier(s)
10.1101/lm.032961.113.
Publication Date
2014-04-01
Publication Title
Learning and Memory
Volume
21
Issue
4
First Page
180
Last Page
184
Keywords
Subject
Community
Department of Psychological Sciences
Permalink https://oaks.kent.edu/psycpubs/9
Cullen, P., Dulka, B., Ortiz, S., Riccio, D., & Jasnow, A. (2014). GABA-mediated Presynaptic Inhibition is Required for Precision of Long-term Memory. Learning and Memory. https://doi.org/10.1101/lm.032961.113.
Cullen, Patrick, Brooke Dulka, Samantha Ortiz, David Riccio, and Aaron Jasnow. 2014. “GABA-Mediated Presynaptic Inhibition Is Required for Precision of Long-Term Memory”. Learning and Memory. https://doi.org/10.1101/lm.032961.113.
Cullen, P., B. Dulka, S. Ortiz, D. Riccio, and A. Jasnow. GABA-Mediated Presynaptic Inhibition Is Required for Precision of Long-Term Memory. Learning and Memory, 1 Apr. 2014, doi:10.1101/lm.032961.113.