This paper attempts to explore an approach of using an automatic semantic analysis tool to enhance the “subject” access to materials that are not included in the usual library subject cataloging process. Using two research samples the authors analyzed the access points supplied by OpenCalais, a semantic analysis tool. As an aid in understanding how computerized subject analysis might be approached, this paper suggests using the three-layer framework that has been accepted and applied in image analysis, developed by Erwin Panofsky.