Non-infectious RNAs from SARS-CoV-2 excreted in symptomatic and asymptomatic individuals’ feces are detectable in wastewater three to seven days before increases in case counts. However, consistency in the time lag between locations and their usefulness in infection rate predictions is unclear. The potential correlation between excreted virus count (copies/L) and infection case counts in major Cleveland municipal wastewater plants (WWTP) was investigated. SARS-CoV-2 virus gene copies were quantified from Cleveland Westerly, Easterly, and Southerly WWTP from August 2020 to January 2021. Potential correlations of COVID-19 virus averages between wastewater monitoring and clinical testing were assessed. Analysis revealed a site-specific correlation in the three WWTP. Our study suggests that WW virus count trends can be a useful predictor that can aid community leaders in eliminating infections.