Microglia are the innate immune cells of the central nervous system. They also act as the primary phagocytes of the brain, clearing pathogenic material to ensure brain health and homeostasis. Microglia exhibit a variety of morphological states. These states are related to the activation and the functionality of microglia. Our focus uses beta-amyloid peptides to better understand the role of morphology in Alzheimer's disease. This research poses to demonstrate the capabilities of scanning electron microscopy (SEM) to assist in making a distinct and measurable analysis of microglia characteristics in variable inflammatory conditions. The measurable alterations of microglia will assist in both our understanding of microglia’s morphological response in neurodegeneration as well as constructing therapeutics that could assist in the recovery of microglia homeostasis.