Two broadly different approaches to spiritual practice exist within virtually every religious tradition. Though the specific characterization and evaluation of these different practices vary among authors, their general nature is reasonably clear. The exoteric path represents the more conventional approach to religion involving ongoing participation in the practices and activities of an established religious community (synagogue, church, mosque, temple, etc.). Alternatively, the esoteric path tends to be more individualistic and mystical in orientation. Within a given tradition, the two approaches are never in opposition to each other but can nonetheless involve complex, bivalent inter-relations. The present paper examines these two forms of practice in terms of their informational characteristics. It is primarily concerned with the amount of information each style of practice generates and processes within a small set of general but relevant contexts. It shows that the two styles of practice result in highly characteristic differences in the generation and processing of information. In addition, the paper argues that important consequences of these differences concern how they both reflect and impact the practitioner’s religious faith and their sense of self.