Open Access Kent State (OAKS)

Background and Purpose: This pilot randomized controlled trial evaluated the effects of 12 sessions of patient-specific adaptive dynamic cycling (PSADC) versus non-adaptive cycling (NA) on motor function and mobility in individuals with Parkinson’s disease (PD), using inertial measurement unit (IMU) sensors for objective assessment. Methods: Twenty-three participants with PD (13 in the PSADC group and 10 in the NA group) completed the study over a 4-week period. Motor function was measured using the Kinesia™ sensors and the MDS-UPDRS Motor III, while mobility was assessed with the TUG test using OPAL IMU sensors. Results: The PSADC group showed significant improvements in MDS-UPDRS Motor III scores (t = 5.165, p < 0.001) and dopamine-sensitive symptoms (t = 4.629, p = 0.001), whereas the NA group did not improve. Both groups showed non-significant improvements in TUG time. IMU sensors provided continuous, quantitative, and unbiased measurements of motor function and mobility, offering a more precise and objective tracking of improvements over time. Conclusions: PSADC demonstrated enhanced treatment effects on PD motor function compared to NA while also reducing variability in individual responses. The integration of IMU sensors was essential for precise monitoring, supporting the potential of a data-driven, individualized exercise approach to optimize treatment outcomes for individuals with PD.

Introduction

The purpose was to examine the prevalence of low energy availability (LEA), explore dietary behaviors in men collegiate gymnasts (n = 14), and investigate the relationships between energy availability (EA), body composition, and plyometric performance.

Methods

Body composition was measured using air displacement plethysmography. Lower- and upper-body peak power (PWRpeak) and modified reactive strength index (RSI_mod) were calculated from countermovement jump (CMJ) and plyometric push-up (PP) assessments. Energy expenditure was tracked over 3 days, while daily energy and macronutrient intake were recorded. EA was calculated and used to categorize athletes into LEA and non-LEA groups. Pearson correlation coefficients were used to examine relationships between EA, body composition, and performance metrics.

Results

85.7% of athletes (n = 12) exhibited LEA (20.98 ± 5.2 kcals/kg FFM), with non-LEA athletes (n = 2) marginally surpassing the <30 kcal/kg of fat-free mass (FFM) threshold (30.58 ± 0.2 kcals/kg FFM). The cohort (n = 14) consumed insufficient energy (30.5 ± 4.5 kcal/kg/day) and carbohydrates (3.7 ± 1.1 g/kg/day), resulting in LEA (22.36 ± 5.9 kcal/kg/FFM). EA was not correlated with body composition or performance metrics.

Discussion

A high prevalence of LEA may exist in men gymnasts, largely due to a low relative energy and carbohydrate intake.

The rapid advancement of Generative Artificial Intelligence (GenAI) models, particularly ChatGPT, has sparked widespread discussion among educators and researchers regarding their potential implications for education. This study presents a comprehensive taxonomy of GenAI in academia and education, encompassing a wide range of applications, challenges, ethical considerations, and future prospects. Drawing on a scoping review of 453 articles, including the 50 most cited works throughout 2023, the taxonomy provides a state-of-the-art analysis of the current landscape of GenAI in education. The taxonomy offers a theoretical framework that aligns with the current discourse in GenAI and education, providing a critical evaluation of the existing literature and proposing innovative perspectives and solutions. The practical implications of the taxonomy for educators, researchers, and policymakers are highlighted, emphasizing the need for ethical considerations and informed policies to maximize the benefits of GenAI while minimizing its risks and negative impacts.

The conversion of Adenosine (A) to Inosine (I), by Adenosine Deaminases Acting on RNA or ADARs, is an essential post-transcriptional modification that contributes to proteome diversity and regulation in metazoans including humans. In addition to its transcriptome-regulating role, ADARs also play a major part in immune response to viral infection, where an interferon response activates interferon-stimulated genes, such as ADARp150, in turn dynamically regulating host-virus interactions. A previous report has shown that infection from reoviruses, despite strong activation of ADARp150, does not influence the editing of some of the major known editing targets, while likely editing others, suggesting a potentially nuanced editing pattern that may depend on different factors. However, the results were based on a handful of selected editing sites and did not cover the entire transcriptome. Thus, to determine whether and how reovirus infection specifically affects host ADAR editing patterns, we analyzed a publicly available deep-sequenced RNA-seq dataset, from murine fibroblasts infected with wild-type and mutant reovirus strains that allowed us to examine changes in editing patterns on a transcriptome-wide scale. To the best of our knowledge, this is the first transcriptome-wide report on host editing changes after reovirus infection. Our results demonstrate that reovirus infection induces unique nuanced editing changes in the host, including introducing sites uniquely edited in infected samples. Genes with edited sites are overrepresented in pathways related to immune regulation, cellular signaling, metabolism, and growth. Moreover, a shift in editing targets has also been observed, where the same genes are edited in infection and control conditions but at different sites, or where the editing rate is increased for some and decreased for other differential targets, supporting the hypothesis of dynamic and condition-specific editing by ADARs.

Objective: To describe and analyze how Extension nutrition educators in one state system transitioned from primarily face-to-face to virtual nutrition education programming.

Design: This exploratory case study gathered data through nutrition educator interviews, virtual program delivery guides, and nutrition educators’ program impact statements.

Setting: Southeastern State Extension system in late 2022.

Participants: The sample included 15 participant interviews, multiple virtual program delivery guides, and 43 program impact summaries.

Phenomenon of Interest: The use of Cultural Historical Activity Theory as a framework to explore educators’ learning process with virtual program delivery and how this learning influenced community nutrition program delivery choices.

Analysis: Qualitative data was analyzed with ATLAS.ti using a priori coding.

Results: Two key findings emerged from the data: educators were more likely to deliver programs in a virtual setting when the programs aligned with their values and skills, and educators preferred flexible program curricula and delivery guides because it allowed them to address their community’s specific needs.

Conclusions and Implications: Educators plan to continue to deliver certain community nutrition programs virtually. Future research is needed to explore additional perspectives on virtual delivery, such as program participants and state program managers.