The conversion of Adenosine (A) to Inosine (I), by Adenosine Deaminases Acting on RNA or ADARs, is an essential post-transcriptional modification that contributes to proteome diversity and regulation in metazoans including humans. In addition to its transcriptome-regulating role, ADARs also play a major part in immune response to viral infection, where an interferon response activates interferon-stimulated genes, such as ADARp150, in turn dynamically regulating host-virus interactions. A previous report has shown that infection from reoviruses, despite strong activation of ADARp150, does not influence the editing of some of the major known editing targets, while likely editing others, suggesting a potentially nuanced editing pattern that may depend on different factors. However, the results were based on a handful of selected editing sites and did not cover the entire transcriptome. Thus, to determine whether and how reovirus infection specifically affects host ADAR editing patterns, we analyzed a publicly available deep-sequenced RNA-seq dataset, from murine fibroblasts infected with wild-type and mutant reovirus strains that allowed us to examine changes in editing patterns on a transcriptome-wide scale. To the best of our knowledge, this is the first transcriptome-wide report on host editing changes after reovirus infection. Our results demonstrate that reovirus infection induces unique nuanced editing changes in the host, including introducing sites uniquely edited in infected samples. Genes with edited sites are overrepresented in pathways related to immune regulation, cellular signaling, metabolism, and growth. Moreover, a shift in editing targets has also been observed, where the same genes are edited in infection and control conditions but at different sites, or where the editing rate is increased for some and decreased for other differential targets, supporting the hypothesis of dynamic and condition-specific editing by ADARs.

Democratic bias in polls reached record highs in recent elections. The Shy Trump Voter Hypothesis claims some voters feel pressure to hide plans to vote for Trump. Despite several scholarly efforts to assess whether shy Trump voters contribute significantly to Democratic bias, the jury is still out. We undertake a thorough investigation using the longstanding, and more general, social desirability framework to consider why some survey subjects might be shy about revealing their support for any candidate. We randomly assign voters to either report the candidate they would SAY they would vote for if they wanted to make the best impression on others or the worst impression. In a new addition to this experiment, we then return to each voter with the opposite condition. Doing so allows us to investigate the causes and consequences of the social pressures voters feel when discussing which candidate they support. We show that the pressures voters feel are a function of the partisan context in which they live and we focus on voters that feel pressure to say they support a candidate other than the candidate of the party with which they identify. Although we demonstrate that cross-pressured partisans are more likely to say they intend to vote for the other party’s candidate than unpressured partisans, they occur on both sides and so polling bias created by them (should they revert to their party’s candidate in the voting booth) is likely reduced in the aggregate.

Emotion differentiation (ED) – complexity in the mental representation and description of one’s emotional experiences – is important for mental health. However, less is known whether ED can be enhanced in adults. We investigated if scaffolding emotion language use during affect labelling – initial provision of emotion word prompts (close-ended) followed by free response (open-ended) – impacts ED and psychological health. Utilising a crossover design, 92 college students completed questionnaires assessing psychological health at three time-points and ecological momentary assessment of emotions, affect valence and emotional self-efficacy for 14 days. Participants were randomised to the “scaffolding” group, where they reported emotions using the close-ended (7 days) followed by open-ended (7 days) approach, or the reverse sequence (control group). We extracted two ED indices: traditional intraclass correlation coefficient from close-ended reports and novel specificity index from open-ended reports. Primary analyses examined group differences across weeks while exploratory analyses examined moment-to-moment differences using multilevel modelling. Relative to controls, the scaffolding group demonstrated greater ED during open-ended emotion reporting of negative emotions and associated shifts in negative affect and emotional self-efficacy. There were no significant group differences in psychological symptoms. Results provide preliminary evidence that scaffolding may enhance ED and have implications for psychological intervention.

Objective: There is continued interest in understanding what leads people to engage in CDC-recommended COVID-19 prevention behaviors. We tested whether fear and COVID-19 worry would replicate as the primary drivers of six CDC recommended prevention behaviors. Methods and Measures: We recruited 741 adult participants during the second major peak of the COVID-19 pandemic in the United States (early 2021). Using very similar methods to the original study, participants completed a 10-day daily diary. Mixed effects models identified the strongest predictors of each individual prevention behavior as well as approach and avoidance behavior clusters. Results: At the between-person level, COVID-19 worry, COVID-19 perceived susceptibility, fear, and positive emotions all had positive zero-order associations with the prevention behaviors. However, with all predictors in the same model together, primarily COVID-19 worry remained significant for both the individual behaviors and behavior clusters. At the within-person level, only fear related to assessing oneself for COVID-19 and approach behaviors on the same day, but not the next day. Mediational analyses suggested COVID-19 worry, but not COVID-19 susceptibility, mediated the links between fear and approach/avoidance behaviors. Conclusion: Findings replicated worry about yourself or a loved one getting COVID-19 as the strongest predictor of prevention behaviors.

Background
Most studies on later-life health in India focus on families, with far less attention given to the health repercussions of neighbourhood conditions among older Indians. We address this limitation in existing research by examining the associations between perceptions of neighbourhood safety and social cohesion and sleep duration and sleep quality among older adults in India.

Methods
Data come from the Study on Global Aging and Adult Health (WHO-SAGE), India 2015 wave 2, with a sample of 7118 adults aged 50 years and above. Sleep quality and duration were assessed using subjective responses. Multivariable logistic and linear regression analyses were employed to test the research hypotheses.

Results
Prevalence of poor sleep quality was higher among older adults living in unsafe neighbourhoods (4.46%) than peers residing in safe neighbourhoods (3.52%), and it was also higher among those living in neighbourhoods with poor social cohesion (5.31%) than counterparts who lived in socially cohesive communities (3.10%). Older adults in neighbourhoods with poor social cohesion had higher odds of reporting compromised sleep quality (adjusted odds ratio 1.75, CI: 1.22–2.51) than those living in socially cohesive neighbourhoods. Moreover, compared to those who perceived they were living in safe neighbourhoods, their peers who perceived their neighbourhoods as unsafe reported shorter sleep duration, with a negative beta coefficient of −0.27 (CI: −0.45 to −0.085).

Conclusion
That perceived unsafety and poor social cohesion within one's neighbourhood are associated with compromised sleep reflects the significance of making neighbourhoods safer and more integrated for later-life sleep health. In addition to micro-level strategies (e.g., balanced nutrition and physical activity), efforts to improve sleep health should optimise macro-level opportunities, such as rehabilitating and revitalising neighbourhoods, which may alleviate sleep disturbances and improve sleep outcomes among older adults.

Objective: Participation in college athletics has traditionally been presumed to counter poor mental health outcomes including death by suicide. While previously reported incidents generally involve male football players, recent incidents suggest changing trends in frequency, sport, and sex. This research aims to summarize the breadth and limitations of existing research on death by suicide among U.S. collegiate student-athletes.

Participants and Methods: This scoping review followed Joanna Briggs Institute guidance. Afinal sample of 19 research studies were identified through a comprehensive search including APAPsychINFO, PubMed, MEDLINEComplete, SPORTDiscus, and CINAHLdatabases and Gray Literature sources.

Results: Most studied outcomes were suicidal ideation and attempt. Research on assessment of suicide prevention interventions for student-athletes is lacking. 

Conclusions: The paucity of research found on suicidal behaviors among collegiate student-athletes, including a lack of intervention research, in conjunction with recent trends suggest the need for a renewed focus on this topic.