Memory reconsolidation refers to the process by which a memory is reactivated or retrieved, that information then becomes malleable and must undergo re-storage as the memory is updated. State-dependent memory is evident when there is a mismatch in the cues associated with a memory between learning or storage and retrieval. In Experiment 1a we showed that MK-801, an NMDA receptor antagonist, impaired memory for reconsolidation. Experiment 1b replicated previous work by showing that MK-801 administered peripherally in rats produced state dependent memory for passive avoidance (Flint, Noble, & Ulmen, 2013). In Experiment 2 rats received intracerebroventricular (icv) cannula implants into the left lateral ventricle. In Experiment 3 rats received bilateral dorsal hippocampal cannula implants. All rats were trained in passive-avoidance and, 48 hours later, given a reactivation of the training via exposure to the passive avoidance chamber. Immediately following reactivation, animals were infused with either MK-801 or saline. Then, 48 hours after reactivation and 10 minutes prior to test, animals were infused with MK-801 or saline and tested. The data suggests that MK-801 produced state-dependent reconsolidation for passive-avoidance when given peripherally and centrally via icv and dorsal hippocample infusions.
David C. Riccio
Aaron M. Jasnow