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| Abstract |
Neurological disorders such as multiple sclerosis and Alzheimer’s disease are a result of decreased levels of N-acetylaspartate (NAA) in the brain. NAA is a brain-specific mitochondrial metabolite that plays a role in lipogenesis and myelination within the central nervous system. NAA is synthesized by an N-acetyltransferase enzyme that is encoded by the gene N-acetyltransferase-8-like (NAT8L) and metabolized into acetate and aspartate by the enzyme aspartoacylase (ASPA) in oligodendrocytes. Oligodendrocytes are neuronal cells responsible for myelinating the central nervous system axons. This study is sought to examine the changes in myelin lipids using brains of postmortem NAT8L knockout mice, which were unable to synthesize NAA. Western blotting and immunohistochemistry will be performed to measure the effects of NAA deficiency on myelin.
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Faculty Mentor
Jennifer McDonough |
| Modified Abstract |
N-acetylaspartate (NAA) is a brain-specific mitochondrial metabolite that plays a role in lipogenesis and myelination within the central nervous system. Several neurological disorders, including Alzheimer’s disease and multiple sclerosis, are a result of decreased levels of NAA. This study sought to examine the changes in myelin lipids using brains of postmortem NAT8L knockout mice, which were unable to synthesize NAA. Western blotting and immunohistochemistry were used to measure the effects of NAA deficiency on myelin. |
| Permalink | https://oaks.kent.edu/ugresearch/2020/biologyecology/effects-brain-nat8l-knockdown-myelin |
Arnold, N. Effects of Brain NAT8L Knockdown on Myelin . https://oaks.kent.edu/node/10236
Arnold, Natalie. n.d. “Effects of Brain NAT8L Knockdown on Myelin ”. https://oaks.kent.edu/node/10236.
Arnold, N. Effects of Brain NAT8L Knockdown on Myelin . https://oaks.kent.edu/node/10236.