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| Abstract |
Human chorionic gonadotropin (hCG) is a heterodimeric glycoprotein involved in reproductive function known to bind the luteinizing hormone receptor (LHR). LHR activation has been shown to inhibit function at high doses. Importantly, in the APP/PS1 Alzheimer’s disease mouse model, known to have increased susceptibility to seizures, we have observed that mortality due to seizures is significantly reduced in animals treated with intracerebral (ICV) hCG. Therefore, to more directly address if hCG has anti-convulsant effects we used a model of epilepsy (kiantic acid administration) to induce convulsions in the presence and absence of chronic ICV hCG treatment in WT and APP/PS1 mice. The seizure induction and severity were scored using a seizure scale and neuronal changes/damage was determined by Tunnel staining. Our preliminary data in APP/PS1 suggests hCG may reduce susceptibility and severity of seizures in this model of epilepsy.
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| Contributor(s) |
Faculty Mentor
Gemma Casadesus-Smith |
| Modified Abstract |
Human chorionic gonadotropin (hCG) is a heterodimeric glycoprotein involved in reproductive function known to bind the luteinizing hormone receptor (LHR). In the APP/PS1 Alzheimer’s disease mouse model, known to have increased susceptibility to seizures, we have observed that mortality due to seizures is reduced in animals treated with intracerebral (ICV) hCG. Therefore, to more directly address if hCG has anti-convulsant effects we used a model of epilepsy (kiantic acid administration) to induce convulsions in the presence and absence of chronic ICV hCG treatment in WT and APP/PS1 mice. The seizure induction and severity were scored using a seizure scale and neuronal changes/damage was determined by staining. Our preliminary data in APP/PS1 suggests hCG may reduce susceptibility and severity of seizures in this model of epilepsy. |