With the growing obesity epidemic, we investigate mechanisms to increase caloric expenditure in mice by including muscle thermogenesis. Muscle thermogenesis can be acutely induced by predator odor; however, other stimuli may more potently activate thermogenesis. We investigated the potential multimodal activation of muscle thermogenesis in mice, hypothesizing that a greater thermogenic activation will be seen when exposed to the multimodal stimulus. After habituation to experimental conditions, mice were presented with three stimuli in randomized order: control, ferret odor, and the multimodal stimuli. We observed a trend toward a similar effect with the multimodal predator and rat odor toward muscle thermogenesis. Later studies explored different predator odors individually. Cat fur showed no significant enhancement of response, though rat odor may show significance with additional statistical power.