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Detection of BHMT in Oligodendrocytes

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  4. 2019 - Kent State University Undergraduate Symposium on Research, Scholarship and Creative Activity
  5. Detection of BHMT in Oligodendrocytes
Author(s)
  • Christian Richardson
Abstract

Multiple sclerosis (MS) is a neurodegenerative disease in which the body’s immune system attacks the nervous system leading to degradation of the myelin sheath surrounding nerve cells. Methionine metabolism is a pathway that is negatively affected in MS. In MS, inflammation and increased reactive oxygen species lead to a buildup of homocysteine which can cause complications. Further, SAM is down-regulated in MS causing decreased methylation and subsequent gene expression. To counter this problem, BHMT is an enzyme that is activated by betaine and helps prevent the accumulation of homocysteine and is therefore able to proceed with the conversion into methionine. BHMT is present in oligodendrocytes but the reason is not yet known. The focus of this project is to look at BHMT expression and potential co-localization with other proteins through immunocytochemistry. This information will give us a better understanding of BHMT and its role in oligodendrocytes.

Format
Conference Proceeding
Publication Date
2019-04-09
Contributor(s)
Faculty Mentor
Dr. Jennifer McDonough
Sarah Sternbach
Dr. Earnest Freeman
Subject
  • Medical Biochemistry
  • Medical Cell Biology
  • Nervous System Diseases
Community
Division of Research and Sponsored Programs
Modified Abstract

Multiple sclerosis (MS) is a neurodegenerative disease in which the body’s immune system attacks the nervous system leading to degradation of the myelin sheath surrounding nerve cells. In MS, inflammation and increased reactive oxygen species lead to a buildup of homocysteine which can be prevented by activation of BHMT by betaine. BHMT is present in oligodendrocytes which may be neuroprotective. The focus of this project is to look at BHMT expression and potential co-localization with other proteins through immunocytochemistry.

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