Viruses in the Flaviviridae family, such as West Nile Virus (WNV) and Dengue, spread by arthropods (mosquitoes and ticks), represent a major threat to global health. Since 2000 there was a major uptick in the number of flaviviral infections worldwide, due to global climate change, and changes in patterns of urbanization and migration. First found in 1999, WNV spread across the US by 2004, resulting in 22,000+ cases of neuroinvasive disease and 2,000+ deaths (CDC 2017). Zika virus (ZIKV) is another emergent pathogen causing a significant concern because of neurodevelopmental defects. As vectors expand, so do the range of local viral transmissions and frequency of infections. Thus, it is important to understand the nature of symptoms associated with flaviviral infections, so that better surveillance programs can be established. Here we conducted literature review to identify which flaviviruses have documented neurological symptoms, including psychiatric, neurodegenerative, and developmental disorders. Knowledge of such associations with specific viruses can be used in multiple ways, including identification of those likely at risk of developing neurological disorders and/or expanding the list of symptoms to look for. Furthermore, better understanding of molecular underpinnings of neurological symptoms (e.g., if driven by a flavivirus activating the host’s TLR3 pathway) may aid in the development of therapies and interventions. Overall, knowing the breadth of symptoms associated with flaviviral infections can open up opportunities for preventative treatment before neurological symptoms are detected.