Sensitive Electrochemical Detection of Peroxynitrite Using Bis-(4-amino-aryl)-selenide Modified Interfaces

Division of Research and Sponsored Programs
Author(s)
Abstract

Azeroual Sami1, Haitham Kalil2, Mekki Bayachou2,3, and Farid Fouad4,*

1Department of Chemistry & Biochemistry, Kent State University, Kent, Ohio 44240

2Department of Chemistry, College of Science, Cleveland State University, Cleveland, Ohio 44115

3Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195

4Department of Chemistry & Biochemistry, Kent State University at East Liverpool, East Liverpool, Ohio 43920

In this work, we present the synthesis and grafting of 4,4'-diaminodiaryl selenides on graphite and indium-tin oxide electrodes for peroxynitrite sensing interfaces using voltammetry and dose-response amperometry. Modified interfaces are characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS).

The selenide modified electrodes showed a significant enhancement in peroxynitrite oxidative current compared to controls. The enhancement in peroxynitrite signal is the result of an electrocatalytic mechanism where the grafted selenide compound at the oxidized state mediates the oxidation of peroxynitrite at the electrode surface. To the best of our knowledge, this is the first time a selenium-based compound electrochemically grafted at an electrode surface is used for catalytic detection and quantification of peroxynitrite.
Format
Conference Proceeding
Publication Date
2019-04-09
Contributor(s)
Faculty Mentor
Dr. Farid
Subject
Community
Division of Research and Sponsored Programs
Modified Abstract

In this work, we present the synthesis and grafting of 4,4'-diaminodiaryl selenides on graphite and indium-tin oxide electrodes for peroxynitrite sensing interfaces using voltammetry and dose-response amperometry. Modified interfaces are characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS).

The selenide modified electrodes showed a significant enhancement in peroxynitrite oxidative current compared to controls. The enhancement in peroxynitrite signal is the result of an electrocatalytic mechanism where the grafted selenide compound at the oxidized state mediates the oxidation of peroxynitrite at the electrode surface. To the best of our knowledge, this is the first time a selenium-based compound electrochemically grafted at an electrode surface is used for catalytic detection and quantification of peroxynitrite.
Permalink https://oaks.kent.edu/ugresearch/2019/sensitive-electrochemical-detection-peroxynitrite-using-bis-4-amino-aryl-selenide
Azeroual, S. (2019). Sensitive Electrochemical Detection of Peroxynitrite Using Bis-(4-amino-aryl)-selenide Modified Interfaces (1–). https://oaks.kent.edu/node/7933
Azeroual, Sami. 2019. “Sensitive Electrochemical Detection of Peroxynitrite Using Bis-(4-Amino-Aryl)-Selenide Modified Interfaces”. https://oaks.kent.edu/node/7933.
Azeroual, Sami. Sensitive Electrochemical Detection of Peroxynitrite Using Bis-(4-Amino-Aryl)-Selenide Modified Interfaces. 9 Apr. 2019, https://oaks.kent.edu/node/7933.